Straddling the Tennessee/North Carolina border, the Smoky Mountain region is one of America's most-visited wilderness areas. And why not? The rolling hills, extensive wilderness areas, and deep gorges are home to some of the country's best adventures. Add in the southern basecamp towns of Knoxville, Tennessee, and Asheville, North Carolina, and you'll have all the ingredients for an all-American getaway. Here's what you need to know to make it happen.